This paper reviews the literature on the national information infrastructure (NII) initiative in general and Malaysia’s NII in particular. In the advent of information technology (IT) revolution and its positive impacts to the productivity growth, the economic growth and international competitiveness, almost every nation is looking for its very own NII as a strategic move in its development strategies. The discussion in this paper emphasizes on the science or technology parks in the context of physical infrastructure in NII. In this context, the Malaysia’s NII, particularly the establishment of the MSC is reviewed whereby the vision, experiences, issues and challenges of the MSC were highlighted. The author contends that among major issues and challenges which MSC needs to address are as follows: i) achieving a critical mass of technical and management talent pool; ii) spawning and nurturing critical mass of ICT entrepreneurs; iii) bridging the funding gap between the ICT entrepreneurs and the investors, especially the venture capitalists.; and iv) attracting world class ICT companies to have sizeable operations and presence. Funding of ICT entrepreneurship constitutes the core cause in the first three issues and challenges identified above. Thus, there is an urgent need to address it in order for MSC to achieve its role as the new engine of growth in the overall implementation of the Malaysian’s NII.